Tissue engineered vascular grafts for pediatric cardiac surgery
نویسندگان
چکیده
منابع مشابه
Tissue-Engineered Blood Vessels in Pediatric Cardiac Surgery
Pediatric cardiovascular surgeons often encounter patients requiring surgical intervention utilizing foreign materials to repair complex lesions. However, the materials that are commonly used lack growth potential, and long-term results have revealed several material-related failures, such as stenosis, thromboembolization, calcium deposition, and risk of infection. To solve these problems, in p...
متن کاملSilk-based electrospun tubular scaffolds for tissue-engineered vascular grafts.
Electrospinning was used to fabricate non-woven nanofibrous tubular scaffolds from Bombyx mori silk fibroin using an all aqueous process. Cell studies and mechanical characterization tests were performed on the electrospun silk tubes to assess the viability of their usage in bioengineering small-diameter vascular grafts. Human endothelial cells and smooth muscle cells were successfully cultured...
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The first approach is attractive for the possibility of obtaining a fully formed, ready-made transplant with a close to natural microarchitecture. The following conditions are necessary: a sufficiently high rate of resorption of the scaffold with simultaneous structural self-organization of the tissue and the acquisition of anatomical and functional characteristics identical to the replaced ele...
متن کاملSurgical technique for the implantation of tissue engineered vascular grafts and subsequent in vivo monitoring.
The development of Tissue Engineered Vessels (TEVs) is advanced by the ability to routinely and effectively implant TEVs (4-5 mm in diameter) into a large animal model. A step by-step protocol for inter-positional placement of the TEV and real-time digital assessment of the TEV and native carotid arteries is described here. In vivo monitoring is made possible by the implantation of flow probes,...
متن کاملDelivery of Antioxidant and Anti-inflammatory Agents for Tissue Engineered Vascular Grafts
The treatment of patients with severe coronary and peripheral artery disease represents a significant clinical need, especially for those patients that require a bypass graft and do not have viable veins for autologous grafting. Tissue engineering is being investigated to generate an alternative graft. While tissue engineering requires surgical intervention, the release of pharmacological agent...
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ژورنال
عنوان ژورنال: Translational Pediatrics
سال: 2018
ISSN: 2224-4336,2224-4344
DOI: 10.21037/tp.2018.02.01